Steroid Hormone Synthesis

The switch that turns on steroid hormone synthesis is cellular factor cAMP. cAMP and its related enzyme protein kinase A induce steroid-stimulating hormone release from the pituitary gland. These peptide-stimulating hormones signal the gonads and adrenal glands to synthesize steroid hormones.

Note that steroid hormone synthesis could be inhibited by high cholesterol levels. Steroid production involves cholesterol synthesis in the mitochondria. High plasma cholesterol levels inhibit cholesterol synthesis

and therefore may suppress steroid hormone production. The most effective factors promoting anabolic steroid activity to reach a maximum anabolic state are cellular factor cAMP, low serum cholesterol, and high mitochondrial capacity.

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