Indices of ventilatory control have a wide normal range and are subject to overinterpretation.
occlusion pressures in general, and P0.1 in particular, are difficult to interpret without additional measurements of mechanics and control events through the whole respiratory cycle, which are usually not available. P0.1 is a valid index of neural output only at FRC. Breath-to-breath scatter in the data requires averaging of many breaths to obtain precise results. The theoretical issues regarding measurement and interpretation have been reviewed (41).
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