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A completely flat ventilatory response may identify defective chemoreceptor or brainstem function, but lesser abnormalities are difficult to interpret.

Occlusion pressure (P0.1) is relatively easy to measure. Marked discrepancies between occlusion pressure and minute ventilation point to a lung disease causing substantial increase in airway resistance or lung elastance. Usually, however, such a problem is clinically evident and better evaluated by spirometry.

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