There are a number of advantages to measuring MSV as an indicator of respiratory muscle endurance, the most important of which is its close resemblance to the task performed during exercise. It therefore provides clinically relevant data that can be related to function. Second, it is probably a measure of both inspiratory and expiratory muscle endurance because in normal subjects there appear to be decrements in both in-spiratory and expiratory function after MSV maneuvers (39). Finally, maximum ventilatory maneuvers result in evidence of diaphragm fatigue (39-41). Interestingly, this does not appear to be true for patients with COPD (42).
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