All three of these compounds are called beta -agonists, which means that they stimulate beta receptor sub typesl,2, and 3. Clenbuterol is a beta-2 receptor specific agonist. This means that its fat burning effect is due to specific stimulation of beta-2 receptors. Ephedrine is a non-specific beta-receptor agonist. Meaning its effects are due to stimulation of beta 1,2,and 3 receptors. Norephedrine (phenylpropanolamine) is a non-specific beta-receptor agonist as well, but seems to effect beta 2 receptors in a slightly different way.
All beta agonist affect the fat burning process through mild thermalgenesis, which of course involves the process of uncoupling.
Clenbuterol administration tended to cause down-regulation of beta-2 receptor activity. Since beta 2 receptors are a major regulator of the fat break down (lipolysis) process, this sucked.
Continuous administration of Clenbuterol allowed the drug to lose its CNS effectiveness after only a few weeks. Regardless of dosage. For this reason, a 2 day on-2 day off protocol was necessary during Clenbuterol use. This approach slowed the adaptive down-regulating response by beta-2 receptors.
Please be patient. I will explain all the "receptor" stuff in a few minutes.
Unlike Clenbuterol, Ephedrine and Norephedrine did not cause an excessive adaptive response and therefore continued to effect thermalgenic activity for months.
Both induce the release of "Noradrenaline", which in turn stimulates all three beta receptor sub types, and both can stimulate the same receptor-sites directly to some degree. Ephedrine products induce the thermalgenic effect by stimulation of all 3 receptor sub types, but 35-40 % of their stimulatory effects are upon type 3 beta receptors.
This is significant because the response governing activity down-regulation of beta 2 receptors is not possible with beta 3 receptors. So ephedrine products have potential long term effectiveness. Simple? Beta-3 receptor stimulation increases the break down of fats. This also results in an increase in uncoupling protein levels. It should be noted that Ephedrine products increase the conversion of T-4 to T-3 by the liver. (Yup!!)
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