For the most part, GH has a direct effect most notable upon adipose (fat) tissue. A fragment of the GH molecule stimulates the B-3 receptors on fat cells. This then triggers lipolysis (fat burning) while simultaneously blocking fat storage.
*Researchers are currently working on creating the unique GH fragment committed to stimulation of the B-3 receptors on adipose tissue for a fat loss drug. With some luck it will clear FDA approval by 2008.
During any type of mass phase there is a large increase in calorie intake to facilitate new growth. When GH is administered during high calorie periods there is little in the way of increased fat accumulation as compared to protocols for mass that lack the drug.
This is due to the fact that, yes, GH helps to block fat accumulation in this environ, but it fails to significantly increase fat expenditure. This is due to the fact that food increases insulin release that in turn blocks fatty acid release from fat cell.
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