Can It Induce Antibodies

Serum antibodies to GHRH develop in most children receiving treatment with subcutaneous sermorelin. Antibody titres decline sharply 3 months after cessation of therapy and are almost undetectable after 9 months. The clinical relevance of these antibodies is uncertain as there is no correlation between their presence and the effects of sermorelin on growth or on the frequency of adverse effects. Similarly, up to one-fifth of children developed anti-growth hormone antibodies after treatment with recombinant growth hormone preparations. Again, the clinical relevance is unclear.

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