When beta agonist compounds are utilized, the body releases adrenaline and nor-adrenaline, which is secreted due to stimulation of the sympathetic nerves. Ultimately, the body has an adaptive response which regulates the long term activity of beta agonist and therefore their thermalgenic value (fat burning effect).
Methylxanthines such as caffeine, enprofylline, forskolin, and theophylline, block or inhibit the body's adaptive response to a respectable degree. Coadministration of methylxanthines with Clenbuterol, ephedrine or norephedrine resulted in a longer and more potent effect/result period. Normally the most effective ratio of ephedrine or norephedrine to caffeine was about 1 to 1 0. (20 mg of Ephedrine to 200 mg of caffeine.) The chemistry behind this is quite complex, but the basic action is this:
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Beta agonists modulate their fat break-down signal through an energy precursor within the cell called cyclic adenosine monophosphate (cAMP).
Compounds called phosphodiesterases counter-act this by breaking down cAMP and the fat loss signal decreases or stops. Methylxanthines either inhibit or block phophodiesterase which is the enzyme that degrades the phosphate in cAMP. Therefore the fat burning effect/thermalgenic value of the chosen beta-agonist signal continues (Sorry, but you made me do the science geek thing.)
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