Young and Adult Mdx Mice

The most widely used mouse model for DMD is the dystrophin-deficient mdx mouse (Bulfield et al. 1984). Mdx mice show minimal clinical signs and usually live up to 22-23 months of age (Chamberlain et al. 2007; Li et al. 2009).

Numerous studies have examined the mdx heart (Bridges 1986; Cohn et al. 2001; Coulton et al. 1988; Grady et al. 1997; Hainsey et al. 2003; Kamogawa et al. 2001; Nakamura et al. 2002; Quinlan et al. 2004). Despite intensive interrogations, only mild cardiac histopathology and some ECG abnormalities are found in mdx mice that are younger than 12 months of age (Bostick et al. 2008a; Chu et al. 2002; Heymsfield et al. 1978; Markham et al. 2005; Nigro et al. 1990; Sadeghi et al. 2002). External stress (such as administration of positive inotropic drug b-isoproterenol or dobutamine) can induce some, but not all, aspects of cardiomyopathy in adult mdx mice (Danialou et al. 2001; Duan 2006a; Yasuda et al. 2005; Yue et al. 2004).

0 0

Post a comment