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Fig. 4.4 The efficacy of overexpression of delta-sarcoglycan in TO-2 hamsters, (a) Recovery of SGs (a. |3, y. and Ô) onto cell membrane of heart and TA muscles at 2.5 months after AAV8 intraperitoneal injection in neonates, (b) Evans blue dye uptake assay results, (c) Serum creatine kinase (CK) levels of wild-type FIB. untreated TO-2. and AAV8-treated TO-2 hamsters measured at different time courses. * Statistically significant (« = 3-5 per group; pcO.Ol). (d) Gross appearance of the hearts (top) and hematoxylin and eosin staining of the transverse sections (bottom) of hearts from 9-month-old wild-type FIB. TO-2 control, or TO-2 treated with AAV at 10-day age. Arrows indicate visible calcification. This figure was previously published in Circulation 112. 2650-2659 by Zhu et al. (2005)

Fig. 4.4 The efficacy of overexpression of delta-sarcoglycan in TO-2 hamsters, (a) Recovery of SGs (a. |3, y. and Ô) onto cell membrane of heart and TA muscles at 2.5 months after AAV8 intraperitoneal injection in neonates, (b) Evans blue dye uptake assay results, (c) Serum creatine kinase (CK) levels of wild-type FIB. untreated TO-2. and AAV8-treated TO-2 hamsters measured at different time courses. * Statistically significant (« = 3-5 per group; pcO.Ol). (d) Gross appearance of the hearts (top) and hematoxylin and eosin staining of the transverse sections (bottom) of hearts from 9-month-old wild-type FIB. TO-2 control, or TO-2 treated with AAV at 10-day age. Arrows indicate visible calcification. This figure was previously published in Circulation 112. 2650-2659 by Zhu et al. (2005)

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