Some interesting notes

*Using androgens with PG'S were noted to be a bad idea for some individuals even if a legal method could be found. Users often reported that their muscles had difficulty functioning due to serious pumps. The upside was that androgen cycles after PGF-2 cycles became very effective again. According to some available literature, PGF-2 use seems to up- regulate androgen receptor counts at an amazing rate.

*PGF-2 prevented the fattening effects of insulin protocols by differentiation while increasing TGF (*See TGF). This was a benefit for those who were insulin resistant or during pre-contest periods.

*In women PGF-2 use would induce severe menstrual cramping.

*Arachidonic acid is found in red meat in fairly high levels. Unfortunately the activity of an enzyme called 5-Lipooxygenase (5-LO) upon arachidonic acid in the presence of estrogen has been linked to prostate cancer. An interesting finding is that inhibition of the 5-LO enzyme triggers massive apoptosis (programmed cell death) in human prostate cancer cells. Ginger seems to inhibit this enzyme and omega-3 fatty acids have a protective effect against prostate cancer.

As I wrote earlier, training and stretching trigger the release of prostaglandins by acting on the 2 enzymes that are responsible for their formation: Phospholipase A2 is increased which results in higher formation of free (unbound) Arachidonic Acid within muscle cells. Then muscular contractions increase COX-2, which transforms the freed arachidonic acid into PG's. The process can continue for days after a workout. At first, PGF-2 is the most elevated of PG production. FGF-2 synthesis is also elevated but in lower amounts at first. As the training induced muscle injury heals, the amount of PGF-2 production increases progressively. (Which is responsible for much of the anabolic reaction to training) It should be noted that there are several different PG's including PGE-1 which is used as an erectile function drug injected directly into the base of the penis. The result is a sort of inflammation: A woody.

The legal and far less effective but safer way to increase PG's is from the increased intake of essential fatty acids (EFA's). Specifically, Linoleic Acid, which is an OMEGA-6 fatty acid, and Alfa Linolenic Acid which is an Omega-3 fatty acid. Gamma Linoleic Acid (GLA) is another Omega-6 Fatty Acid essential for PGF-2 synthesizes. EFA'S are not just health and performance related. These EFA's are so necessary that without them, your body would simply deteriorate away and you die.

I have been amazed at how lacking many new clients diets are in EFA's. The best ratio seems to be 3:1, or about 6 grams of Omega-3 and 2 grams of Omega-6 fatty acids daily for most hard training bodybuilders. The best supplemental source for both is hemp seed oil. It contains the natural 3:1 ratio. Flax seed oil and evening primrose oil are both good sources, the latter, an excellent GLA provider. Yes, it is possible to test "dirty" for "weed" with enough hemp oil.

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