Reported Characteristics

Drug Class: Synthetic Thyroid Hormone. (Oral) Average Reported Dosage: 100-400 MCG daily.

Noted Comments: Significant suppression of thyroid function during use.

Synthroid is a man-made synthetically manufactured version of T-4/L-thyroxine. The average person produces about 76 MCG/d of T-4/L-thyroxine which is then converted by the liver into the more active T-3/L-triiodothyronine. This is true of the oral T-4/L-thyroxine medications as well. The average conversion rate of T-4 to T-3 is about 30-33%/ MCG. Since the conversion of T-4 to T-3 is dependent upon adequate levels of since and selenium, athletes commonly increase daily intake of these minerals during synthetic T-4/L-thyroxine use.

As is the case with all thyroid hormone drug use, most athletes were noted as wiser to begin at a lower dosage of 100 MCG/d and slowly progress to their chosen dosage. Daily dosages of T-4/L-thyroxine that exceed 400 MCG will not increase metabolic rate beyond what is realized at 400 + MCG/d.

Dosages that were increased too rapidly or that were too high commonly resulted in diarrhea, excessive sweating, rapid heart beat, nausea, vomiting, insomnia and trembling.

T-4 drugs suppress endogenous thyroid hormone production significantly. After discontinuance, most athletes experienced a metabolic lag period of 3-15 days before thyroid function rebound occurred. Interesting fact is that most monitored athletes experienced a 120-130 % increase in endogenous thyroid hormones at that point. And some maintain that level permanently.

*See guggulsterones for other possibilities.

(L-diiodothyronine or 3, 5-diiodo-L-thyronine)

Drug Class: Thyroid Hormone. (Oral) Average Reported Dosage: 150-600 MCG daily.

*Minor noted suppression of thyroid function during lower dosage short term (30-35 days) administration.

There are two well known synthetic thyroid hormones commonly administered by bodybuilders known as T-4 and T-3. (*See "Synthroid" and "Cytomel" for more info) However, some have not yet heard of another natural thyroid hormone called T-2 or L-diiodothyronine. The good new is that it is highly active and naturally occurring in some foods such as beef products. It is also non-prescription in many countries. so far. The bad news is that since it works quite well and offers individuals freedom of choice, it probably will not be legal for long.

So far, T-2 seems to be slightly more effective for fat oxidation (burning) than either T-4 or T-3 alone while offering an improved protein sparing-like result. This may be true. T-2 stimulates cellular mitochondria (cellular energy producers) more so than the cell nucleus. This means, unlike T-4 and T-3, T-2 is less likely to activate other cellular functions and more likely to focus upon increased metabolic rate or energy expenditure. Personal experience had shown an excellent synergistic effect between T-2, Norephedrine, and ephedrine plus caffeine. This is due to an interesting interplay between the substances.

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