Reported Characteristics

Active-Life: 10-12 hours

Drug Class: Diuretic (Oral)

Average Reported Dosage: 50-200mg (total) daily

Spironothiazid is a diureteic and an ALDOSTERONE antagonist. This means that it suppresses the water retaining actions of the hormone ALDOSTERONE while lowering water retention by lowering electrolytes (potassium, sodium, and calcium). The advantage of the combination is that the potassium absorption effect by the spironolactone can be mediated by the hydrochlorthiazide. Because of this, some of the potassium loss side effects can be avoided. This is probably a safer choice than LASIX though any diuretic use should be medically monitored. Thiazides also lead to a lower loss of calcium.

Side effects are commonly due to imbalances in electrolytes and fluids. They can include irregular pulse rate, cramps, and light headiness. Since the drug has ANTI-ANDROGENIC quality (spironolactone), men can experience possible gyno, and impotence due to higher dosage and/or prolonged use. These were noted to not occur due to the brief administration period normally employed. According to available literature, it is best to avoid higher potassium intake during use. Dosages were usually 50-150mg a day for no more than 3 days. Dosages were divided into 2-3 daily dosages.

TRADE NAMES

Aldactazide 25/15-MG TABS

Aldactazide 25/50-MG TABS

Spironothiazid 25/25-MG TABS

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