Potassium Sparing Diuretics

Potassium sparing diuretic drugs are often said to be the safest. Though I do not necessarily agree. Drugs such as Aldactone and Aldactazide are examples of this group and they act as Aldosterone antagonist. Aldosterone is the hormone the body uses to regulate water retention endogenously. In short, for now, Aldosterone elevation equals water retention/elevation. Since potassium-sparing diuretics work by inhibiting the activity of Aldosterone, the result is greater sodium and water excretion, and increased potassium retention. Problems arise when athletes ingest additional potassium without the guidance of a doctor daring use of these drugs. Some users assume muscle cramps are due to imbalances of other electrolytes in all but the rarest cases. Supplementation with over the counter potassium products during use can result in heart attack. Personally I disliked the anti-androgen effect of these drugs. Some athletes experience gyno during use and assume it is due to estrogenic activity. They often increase diuretic dosages assuming "with estrogen comes water". Since potassium sparing diuretics require 7-14 days to provide maximum results, dosages can again be easily misjudged. I believe they are not all that safe.

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