Oral Anabolicandrogenic Steroids

Many Anabolic/Androgenic Steroids (AAS) are available in an oral form. Unfortunately some are also quite toxic to the liver. Orally administered AAS are very susceptible to first pass liver deactivation unless chemical molecular structures are altered to make them harder to deactivate. When an oral AAS is swallowed it enters the stomach where it is partially broken down and passed to the small intestines. The small intestines contain a group of enzymes called CYP-450's. These enzymes begin to break down the AAS further in an attempt to deactivate it. The AAS is then absorbed through intestinal mucosa cells and transferred to the liver portal vein for further deactivation into inactive chemicals such as etiocholanone. These chemicals are then conjugated with glucuronic acid and excreted in urine. Up to 100% of the original compound can be deactivated in this process which is known as first pass deactivation.

By altering the steroid molecule structures deactivation can be greatly reduced. Some AAS are made orally active by adding an alkyl (methyl or ethyl) chemical group to the alfa position of the 17th carbon. These are commonly called c17 alfa-alkylated or methylated AAS. This creates a heavy load upon the liver and will alter or affect enzyme and other chemical levels. This is why orals, particularly methyltestosterone and Anadrol-50, are so harmful if administered for prolonged periods and in high dosages. The reason that this alteration is done is that more of the AAS enters the blood stream and remains active for a prolonged period. The reader should note that it is these c17 alfa-alkylated alterations that cause the possible liver dysfunction and not the original testosterone molecule. For this reason Andriol orals are reasonably liver friendly due to the fact that it is not altered in this way.

Like their injectable cousins, oral steroids are also altered for higher or lower ratios of anabolic and androgenic effects. As an example, injectable testosterone is highly androgenic and highly anabolic. By altering the testosterone molecule structure, nortestosterones such as nandrolones are created. This shifts the ratio in favor of anabolic qualities with less androgenic effects. It is true that the higher the androgenic and potential aromatization quality an AAS possesses, the higher the number of negative side effects possible. But the reader should realize that this is not necessarily due to the androgenic quality itself. This is more so due to aromatization to estrogens and its effects upon HPTA function. For this reason, it would seem that a total anabolic steroid with no androgenic effects would be highly effective with an absence of possible negative side effects.

When androgenic qualities/effects are reduced, so are the anabolic qualities/effects reduced. When an AAS is listed as high anabolic or a high androgenic it simply means the ratio has shifted in favor of these qualities due to structural modifications. This is true for both oral and injectable AAS.

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