Does is

(1) Increase cell insulin receptor-site number and sensitivity.

(2) Decreases the amount of glucose/sugar the intestines absorb.

(3) Decrease the amount of glucose/sugar the liver manufactures. (One source of liver glucose production is amino acids/protein).

These three effects explain why clinical administration of Glucophage seldom results in reports of added hypoglycemic effects during administration of the drug alone. However, when combined with insulin injections and/or sulfonylureas (Glipizide) a significant increase in carbohydrate requirements and weight gain is realized.

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