Bottomline Bodybuilding

When it comes to anti-estrogens, the best bet may be not in occupying the receptor sites, as does Clomid, but to compete with the testosterone/estrogen balance. At one time, Proviron was deemed a valid choice as an anti-estrogen agent until some of the sophomoric steroid students argued that it didn't have any direct anti-estrogenic properties. True, but it still looks as if it's the best choice if you feel the need to guard against estrogen build up. It does so because DHT acts as a gyno antagonist. (Yet another thing that has been oddly overlooked.) Even when DHT is applied topically it's been shown to reduce gyno in cases where the gyno hadn't been a chronic condition.

Beyond the direct effect of DHT, Proviron has distinct benefits, the first being that as a derivative of DHT it isn't capable of forming estrogen, yet it has a much higher affinity for the aromatase enzyme (which converts testosterone to estrogen) than does testosterone. That means administering it with another aromatizable compound will prevent estrogen build up due to the fact that DHT binds to the aromatase enzyme so strongly. There's also been some suggestion that Proviron may downgrade the actual estrogen receptor, thereby making it twice as effective at reducing circulating estrogen levels. And because DHT has such a high affinity for SHBG it leaves more free testosterone to impart its anabolic effects.

It makes sense that the use of Proviron is a more practical and rational method of dealing with the possibility of excess estrogen than the aforementioned method of attempting to add a weaker estrogen in the hopes that it will prevent aromatization.

William Llewellyn touches upon this in Anabolics 2000. He says...

"(Proviron) is in contrast to Nolvadex which only blocks estrogen's ability to bind and activate receptors in certain tissues." (such as breast tissue)

In other words, the World Anabolic Reference was right when it stated;

"Proviron cures the problem of aromatization at the root while Nolvadex simply cures the symptoms. "

Proviron in moderate doses has been shown to be remarkably safe and free of side effects in most men. If you must use an anti-estrogen, Proviron is the way go.

(Note: For more information on reducing estrogen, refer to the upcoming chapter "Lower Estrogen -- Naturally").

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