Pyruvate is a naturally occurring product in the body, and is the end product of glycolysis, being the gateway substrate into the Krebs cycle (also known as the citric acid cycle). The Krebs cycle is a cycle of chemical reactions in order to produce ATP or its direct precursors, i.e. it is involved in energy production.

Pyruvate as a supplement is supposed to increase cellular respiration, i.e. speed up the Krebs cycle, therefore promoting ATP production. This may also inhibit fat production (Stanko & Adibi 1986). In reality, there is little evidence that it actually does this, although major drug companies are involved in research. There is no evidence that supplementing with pyruvate will help a bodybuilder achieve his or her goals. However, properly designed research may reveal different outcomes, but this is a way off.

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