In vivo means in the body, and there are loads of supplements which are substrates or derivatives of substrates naturally occurring in the body. These substrates have a wide range of functions and are essential to life. Manufacturers claim that supplementing your diet with more of that substrate will enhance health or performance. For some products the claims are well founded, e.g. creatine, HMB and GABA, but most are not. I will examine if supplemental doses of these chemicals have any benefits to performance.
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