In vivo Alpha-ketoglutarate (AKG) is a Krebs cycle intermediary substrate, so is involved in ATP production. It is also a direct precursor of glutamine in its synthesis (Goldberg & Chang 1978). Theoretically supplementation with AKG should lead to more energy and more glutamine, both beneficial to a bodybuilder. Unfortunately, in vivo things do not work so clear cut, as other factors have to come into play.
It has been suggested that supplementing with AKG may even be better than supplementing with glutamine because of the intestinal cells high demand for glutamine mean much is used up here, whereas nearly all AKG can be absorbed into blood and be taken to other tissues. The problem is that the effects of AKG on exercise performance are not proven, merely hypothesised. I wouldn't use it, but you may want to give it a try.
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